Which lipoprotein particle serves as an intermediate remnant between VLDL and LDL after triglyceride removal?

Which lipoprotein particle serves as an intermediate remnant between VLDL and LDL after triglyceride removal?

• A. Low-density lipoprotein
• B. High-density lipoprotein
• C. Intermediate-density lipoprotein
• D. Chylomicrons

Answer: (C)

When VLDL circulates and triglycerides are removed by lipoprotein lipase, the particle shrinks and becomes a smaller remnant called intermediate-density lipoprotein. This particle, still carrying apolipoproteins like apoE and apoB-100, sits between VLDL and LDL in the processing pathway. From here, it can be taken up by the liver via receptors recognizing apoE, or further processed by hepatic lipase to form LDL, which is richer in cholesterol. Chylomicrons are from dietary fat and are not the immediate remnant after VLDL TG removal, and LDL is the next stage after IDL, not the intermediate remnant itself.

When VLDL circulates and triglycerides are removed by lipoprotein lipase, the particle shrinks and becomes a smaller remnant called intermediate-density lipoprotein. This particle, still carrying apolipoproteins like apoE and apoB-100, sits between VLDL and LDL in the processing pathway. From here, it can be taken up by the liver via receptors recognizing apoE, or further processed by hepatic lipase to form LDL, which is richer in cholesterol. Chylomicrons are from dietary fat and are not the immediate remnant after VLDL TG removal, and LDL is the next stage after IDL, not the intermediate remnant itself.