Which lipoprotein is the primary carrier of endogenous triglycerides from the liver to tissues?

Which lipoprotein is the primary carrier of endogenous triglycerides from the liver to tissues?

• A. Very low-density lipoprotein
• B. High-density lipoprotein
• C. Low-density lipoprotein
• D. Chylomicrons

Answer: (A)

Endogenous triglyceride transport from the liver to tissues is carried by a lipoprotein produced by the liver that is rich in triglycerides. This lipoprotein is dispatched into the bloodstream and meets lipoprotein lipase on capillary walls, which hydrolyzes the triglycerides into free fatty acids for uptake by adipose and muscle tissues. What remains after delivering most of the triglyceride is a smaller remnant that becomes richer in cholesterol, illustrating how this particle reshapes as it distributes lipids. In contrast, other lipoproteins have different primary roles: chylomicrons carry dietary triglycerides from the intestine after meals, HDL is mainly involved in reverse cholesterol transport, and LDL delivers cholesterol to tissues rather than triglycerides. Thus, the lipoprotein that best fits the role of delivering endogenous triglycerides from the liver to tissues is the one formed in the liver and loaded with triglycerides to supply peripheral tissues.

Endogenous triglyceride transport from the liver to tissues is carried by a lipoprotein produced by the liver that is rich in triglycerides. This lipoprotein is dispatched into the bloodstream and meets lipoprotein lipase on capillary walls, which hydrolyzes the triglycerides into free fatty acids for uptake by adipose and muscle tissues. What remains after delivering most of the triglyceride is a smaller remnant that becomes richer in cholesterol, illustrating how this particle reshapes as it distributes lipids. In contrast, other lipoproteins have different primary roles: chylomicrons carry dietary triglycerides from the intestine after meals, HDL is mainly involved in reverse cholesterol transport, and LDL delivers cholesterol to tissues rather than triglycerides. Thus, the lipoprotein that best fits the role of delivering endogenous triglycerides from the liver to tissues is the one formed in the liver and loaded with triglycerides to supply peripheral tissues.