Which enzyme hydrolyzes phospholipids and triglycerides in HDL?

Which enzyme hydrolyzes phospholipids and triglycerides in HDL?

• A. Endothelial lipase
• B. Hepatic lipase
• C. Lipoprotein lipase
• D. CETP

Answer: (A)

Endothelial lipase is the enzyme that targets HDL by trimming its surface lipids, especially phospholipids, and to a lesser extent triglycerides. This activity remodels HDL particles, often producing smaller, more rapidly cleared HDL particles and lowering HDL cholesterol levels. Lipoprotein lipase acts on triglycerides in chylomicrons and VLDL rather than HDL itself, hepatic lipase mainly remodels triglyceride-rich lipoproteins and can affect HDL to some degree but is not the primary HDL phospholipid hydrolyzer, and CETP transfers cholesteryl esters and triglycerides between lipoproteins rather than hydrolyzing lipids in HDL.

Endothelial lipase is the enzyme that targets HDL by trimming its surface lipids, especially phospholipids, and to a lesser extent triglycerides. This activity remodels HDL particles, often producing smaller, more rapidly cleared HDL particles and lowering HDL cholesterol levels. Lipoprotein lipase acts on triglycerides in chylomicrons and VLDL rather than HDL itself, hepatic lipase mainly remodels triglyceride-rich lipoproteins and can affect HDL to some degree but is not the primary HDL phospholipid hydrolyzer, and CETP transfers cholesteryl esters and triglycerides between lipoproteins rather than hydrolyzing lipids in HDL.