In HPLC, the mobile phase is more polar than the stationary phase.

In HPLC, the mobile phase is more polar than the stationary phase.

• A. Reverse Phase HPLC
• B. Capillary Electrophoresis
• C. High Performance Liquid Chromatography (HPLC)
• D. Mass Spectroscopy

Answer: (A)

In reversed-phase HPLC, the stationary phase is nonpolar (hydrophobic) while the mobile phase is polar. This setup means polar compounds interact less with the hydrophobic surface and tend to move through the column more quickly, whereas nonpolar compounds stick to the stationary phase longer and elute later. The term "reverse" contrasts with normal-phase HPLC, where the stationary phase is polar and the mobile phase is nonpolar. So describing the mobile phase as more polar than the stationary phase is exactly the characteristic of reversed-phase HPLC. The other options refer to different techniques or general terms that don’t describe this polarity relationship.

In reversed-phase HPLC, the stationary phase is nonpolar (hydrophobic) while the mobile phase is polar. This setup means polar compounds interact less with the hydrophobic surface and tend to move through the column more quickly, whereas nonpolar compounds stick to the stationary phase longer and elute later. The term "reverse" contrasts with normal-phase HPLC, where the stationary phase is polar and the mobile phase is nonpolar. So describing the mobile phase as more polar than the stationary phase is exactly the characteristic of reversed-phase HPLC. The other options refer to different techniques or general terms that don’t describe this polarity relationship.